A homo [3+2] dipolar cycloaddition: the reaction of nitrones with cyclopropanes.

Yb(NTf2)3-catalyzed [3 + 3] cycloaddition between isatin ketonitrones and cyclopropanes to construct novel spiro[tetrahydro-1,2-oxazine]oxindoles.

Yb(NTf(2))(3)-catalyzed [3 + 3] cycloaddition between isatin ketonitrones and cyclopropanes is described. A variety of spiro[tetrahydro-1,2-oxazine]oxindoles were obtained in moderate to good yields along with good regioselectivities. This is the first example of the intermolecular [3 + 3] cycloaddition between ketone-derived nitrones and cyclopropanes.

Organocatalysis "on water". Regioselective [3 + 2]-cycloaddition of nitrones and allenolates.

The first example of a regioselective and organocatalyzed 1,3-dipolar cycloaddition reaction between conjugated alkynoates and nitrones "on water" is described.

Highly enantioselective and diastereoselective cycloaddition of cyclopropanes with nitrones and its application in the kinetic resolution of 2-substituted cyclopropane-1,1-dicarboxylates.

Density Functional Theory Mechanistic Study of the Regioselectivity of 1,3-Dipolar Cycloaddition Reaction Between Acyclic Nitrones and Norsarkomycin and its Analogues

The 1,3-dipolar cycloaddition reaction (1,3-DC) has offered the opportunity to produce a wide range of heterocyclic compounds [1,2]. These compounds were used to prepare new molecules of crucial importance for both pharmaceutics and industry sector [3]. The application of 1,3-DC reactions in natural product synthesis is heavily dependent upon an understanding of the regioselectivity and chemios...

1,3-Dipolar [3 + 2] cycloaddition reactions of N,C,C-trisubstituted nitrones with ring-acceptor methylenecyclopropanes: a computational study

BACKGROUND 1,3-Dipolar [3 + 2]-cycloaddition of nitrones to the carbon-carbon double bonds of methylenecyclopropanes yields a mixture of regioisomeric 4- and 5-isoxazolidines. The mechanisms of the reactions of N,C,C-trisubstituted nitrones with ring acceptor substituted dimethyl methylenecyclopropanes-1,2-dicarboxylate and aryl methylidene cyclopropanes-1,1-dicarboxylate have been investigated...